Elevated Liver Enzymes

A year ago at Jake’s annual checkup a senior panel was done and his Alk Phos level was elevated at 360. We had follow up 3 and 4 month follow up testing and it was unchanged. No other values were elevated at that time. We had our annual checkup last week and the results of his liver enzyme panel were not good. This time not only was the alk phos elevated to 662 but his ast and alt levels were also elevated, 289 and 687 respectfully. Obviously this was very disheartening as he is clinically asymptomatic. He shows no signs of any problems associated with these results. I immediately got on the internet and started reading to understand more about the potential for liver disease and found your foundation website. I wanted to tap into your experience and knowledge and hopefully get some feedback from you. We have an appointment Monday for xrays. My concern is this is the first time other enzyme levels have been elevated and could this be a fluke or testing error!! I found a round table discussion on this and it suggested repeating the test in 2 to 3 weeks to substantiate the results. I need to have this discussion with my vet and will do so Monday. Another concern is what I am feeding Jake. About six months ago I put him on a raw food diet (Primal). I tried to find info to see if this could be potentiating a liver problem. The only supplements he is on are kelp and a probiotic. I did have him on milk thistle when the initial alk phos level was elevated but only did this for two months. He has been on other nutritional supplements for skin and coat but I stopped those. I forgot he is also on organic coconut oil. There is a local health food store that specializes in dog nutrition and I have been following some of their recommendations for maximizing Jake’s health. Other than this Jake has had occasional ear , skin, and pad issues but for the most part had remained in good health. I might also add we exercise regularly, walking twice a day weather permitting. Needless to say I am quite concerned and any help you can provide would be greatly appreciated. I am considering requesting a consult to see an internal vet specialist. I have some other questions about further testing such as serum bile acid. I might also add that I am in medicine myself and knowing what I know about the human element heightens questions and poses trust issues in the care and treatment of Jake!!! I have had some unpleasant vet experiences and just changed vets so at this point my confidence level is being tested and it scares me… Thanks for listening and I look forward to hearing from you.


Barb and Jake

March 12, 2009 by Lisa  
Filed under Blog


72 Comments on "Elevated Liver Enzymes"

  1. Lou Ann on Wed, 18th Mar 2009 8:22 pm 

    I would be very interested in what you find out about Jake. I feel that I am in a similiar situation as you (See “Can you help?” below your blog.)

    Malie’s ALP is 839 (up from 300-400 over the past 2 years.) The internist did comment that this could be a bad test result. Either way, her liver is in very bad condition.

    Unfortunately, I can’t offer any help because we don’t have an underlying cause. She did test positive for atypical Cushing’s disease, but the thought is this isn’t the basis of her diseased liver. No one wants to think their baby is one of a kind when it comes to ill health.

    If you can, I would strongly suggest an ultrasound with potenital aspirations.

    If you have any updates, I would be interested in hearing them.

    Lou Ann

  2. carol on Tue, 19th May 2009 5:44 pm 

    I do am in shock. My welsh terrier never sick except for allergies and ear infections had blood work and everything checked out fine except for liver, ALKP was 2,000 (yes very high), ALT was 121, GGT was 9 and LIPA was1967. Everything else was normal. Full body e-rays showed all normal including liver size. Did a urine screen this AM, waiting results. Can anyone help, they are saying Cushing or liver disease, how about any other yard poisons or anything else? He was on PRED for allergies but not consistenly maybe a half pill 3 times a month and during the winters none.
    Any other ideas, he is only 8 years old, please help. He also eats Fish and potato Dick Van Patten dog food with 1/4 can daily of Wellness duck or lamb. Normal treats milkbones.

  3. Lucas on Fri, 29th May 2009 1:05 pm 

    Sorry to hear that you all are having problems. Believe me, I can relate. My dachshund has the same problem for years …. symptoms that you have described (a lot like chronic hepatitis).

    Here are some of the (long term) things that I have tried that seems to have helped out a great deal (Please, I strongly advise doing more research and not just taking my word for it):

    * Milk Thistle extract(silymarin). This herb can be found in most pharmacy and/or grocery store. Silymarin protects the liver. (About 240 mg per 100 lbs … do the math. For maximum efficiency, you will need to cylce this herb.)

    * S-AME (S-Adenosylmethionine). This raises glutathione (antioxidant) levels in the liver and aids the liver in detoxifying the vile unwanted gunk. (About 100 mg per 15 lb.). I suggest the internet to get the lower price (this is somewhat pricy … but well worth it for my best bud!) It is also marketed with vets as Denosyl (it’s S-AME, but you pay more for the Denosyl name … you can look this up in the internet for more information).

    * Beef Liver: I supplement my 15 lb dog with 1.5 oz. of beef liver every day. The nutrients in beef liver helps out my dog and it enhances S-AME (as S-AME requires sufficient vit B12, folic acid and other nurtients that beef liver provides). Careful that you don’t feed too much as high levels of iron and vit. a in liver can be toxic.

    * Diet: I’m leary about high protien diets as this usually taxes the liver enormously. I try to keep the protien levels at about 20% – 24% (lower for older dogs). While fish is probably the best choice, my dog loves red meat too much!

    * Exercise: Circulation is always good!

    I would definitely stay away from the PRED … that will really throw off your dog’s internal secretive systems (try fish oil for the allergy inflammation … it’s a lot more effective and not as disruptive to your dog’s system).

    Another important lesson that I learned: Treat the dog and not the test results! Yes, the test results could indicate a problem and you need to pay attention to it. But on the other hand, if you’re dog appears to be comfortable and healthy, then that also goes a long way towards recovery (HOPE is always a good thing!).

    HOPE this helps!!

  4. ALONDRA on Tue, 9th Jun 2009 11:10 am 


  5. Jhn Humenansky on Sun, 12th Jul 2009 12:36 am 

    I have a 5 year old English Setter (Field Variety) and he weighs about 52 pounds. The day after I took him in for his annual checkup he vomited up the entire contents of his morning meal that consisted of one cup of Nutro Brand High Energy dry food. The following two days he kept his food down but vomited up two three times a yellow mucus. He received a rabies shot , lyme vaccine and the other vaccines. Two days after the checkup visit he was taken to the vet and a blood panel showed his liver enzymes were elevated (1200 ALT) X-rays were taken but showed nothing abnormal. Took him back a week later and the liver enzymes were 1800. A week later they had dropped to 1600. He is showing no physical symptoms and is a high energy dog. The vet suggested a liver biopsy however I do not want to risk potential side effects of a liver biopsy at this time. I asked the vet if there was some kind of antibiotic he could suggest and he was put on Metronidazole 500mg 2x/day plus milk thistle and SamE. He has been on this for about three weeks and his liver enzymes are now 2600. He is still showing no symptioms at all and am not sure what to do next. I don’t know if he had a pre-existing condition or what because if he had not vomited after the vaccinations, we never would have checked his blood work. Is it time for a liver biopsy?

  6. Lulu's Dad on Thu, 27th Aug 2009 4:55 pm 

    Hi all,

    My 12 year old dog was diagonalized with crushing, has a grade 3 heart murmur and has hypothyroidism. we had a chest and abdominal ultra sound done in May of this year, it indicated an enlarged heart and an elarged liver and enlarged adrenal glands, no masses were detected.
    The consensious was to put her on Lysodern and before that we did a geriatric blood panel and found that her liver enzymes had elevated tremendously in the past 3 months
    Ast 167 and AlT 611 with an alkaline phosphate of 756.

    We could not put her on the medicine for cushings because of this, as the medicine is metabolized in the liver and it it is not it could lead to toxic shock. The catch 22 is the elevations could be caused by cushings.

    I have booked a consult with a vet who is also a herbalist and will see him this Wednesday. Any suggestions or comments would be greatly appreciated.

  7. Carolyn on Tue, 1st Sep 2009 1:55 pm 

    I would think about having your dog tested for Cushings. My 9 year old peke-a-poo started drinking a TON of water, stopped jumping up on the couch, had a big belly and her head was like a skull. These are all characteristics of Cushings. I had never even heard of Cushings before my dog was diagnosed.

    Good luck,

  8. Lulus Dad on Sat, 5th Sep 2009 5:37 pm 

    Hi Alondara,

    I agree with Carol. Your best bet would be to get your dog tested for cushings. Make sure your vet is experienced with the endocrinal system. Sometimes it saves a lot of precious time and money to get your vet to refer you to an internal specialist. It is slightly more expensive but money well spent.

    Lulu’s Dad

  9. charles puskas on Sun, 6th Sep 2009 12:36 am 

    Our 14 year-old lab-chow mix, Scrappy, won’t eat any food, just some water. The vet said that her enzyme level was 2,299 and that it probably indicates liver problems. Its day three and she’s taken a little chicken broth and some pork, but I don’t know if this can continue through labor day 2009.

    Chuck and Scrappy

  10. Richard on Wed, 9th Sep 2009 9:03 pm 

    I am too facing the lost of my dog. Initially thought that her problem to get up was arthritis because she is 15 years old. Went to the vet and obtained a treatment for that. But also agree to have a blood test. Unfortunately, her enzyme level is high. Don’t remember how much, but by talking with the vet, it was clear that, if it was her dog, she would euthanized her. That decision is based on an evaluation of how happy, a dog can live is such condition and taking consideration of how long she has been living happily.

    Even though it is paintfull to let her go, it is the right choice. Her puppy face doesn’t tell the true, so I have to see behind this, and feel what she would want if she could understand what is happening to her and be able to speak.

  11. Debra on Thu, 10th Sep 2009 5:20 pm 

    Hi Alondra,
    My dog was diagnosed with SARDS, which is blindness overnight. Her symptoms before the blindness were elevated liver enzymes, panting and extreme thirst not to mention UTI’s. The vets were pushing towards Cushings until she went blind. The reason I thought this to be relevant to you is that Daschhund breed has a higher incindence of SARDS. A great book to read on cushings as well as Sards is “Dogs, Diet and Disease” by Caroline D. Levin. She explains the diseases as well as implementing diet and supplement changes. Hope everything works out well for your dog.

  12. Janet on Sat, 19th Sep 2009 3:44 pm 

    I have two Scottish Terriers with extremely high elevated liver counts. We have run every tesy know but nothing conclusive shows up. One dog was very bloated and drinking tons of water. The other just drank a lot of watet. Both had skin problems. After much research we put both dogs on prescriprion Science Diet dog food for liver disease (L-D). It comes in dry and canned. My dogs seem to prefer the dry more than canned. I pour hot, filtered water over it and let it set until it becomes soft. We also put both dogs on Denamarin chewables, which greatly supports the liver. They must be given on an empty stomach, followed by food an hour or so later. Both dogs improved greatly doing these two things though the liver counts remained high. The first dog no longer bloats or throws up, and skin problems have all but vanished. The second dog does not drink nearly as much and her skin has also cleared up. She has no symptoms. The first dog however is drinking continuously, and has now started loosing weight, though her appetite is good. She has great energy, and looks good otherwise. Hope this helps some of you.

  13. Audra on Tue, 29th Sep 2009 11:46 pm 

    I just lost my Scottie to liver, kidney, and pancreatic causes. The first we heard of her problems was two years ago. Her liver enzyme count came back 3,662!!! My vet ran the test four times with the same results; he told us she should be dead. For a year before that we had known that she had Cushing’s Disease. We had been treating her kidneys and adrenal glands with medication, and with the liver problems we added a special, low-protein diet food for her liver. Over the last two years of her life, her liver enzymes went down to 348 right before she died. However, the liver affects the pancreas, and what she died of was pancreatitis. If you are having your dog checked for Cushing’s or liver problems, keep in mind these are all related. Get them thoroughly checked out, and look for any links. Take care of your dogs–your time with them is short and precious.

  14. Alec on Fri, 2nd Oct 2009 2:02 pm 

    Our 11 year old Springer Spaniel has been very lethargic over the few weeks sand we had him at the vet today and blood was taken. The vet called back and said that they thought that there was a high enzyme count but dont know if its liver or kidney. I am really worried i now have to take in a urine sample.

  15. Alec on Tue, 6th Oct 2009 1:08 pm 

    Got the result of the urine test. It shoew blood and was very watery which means that the kidney is not functioning properly, had him back atthe vet today and he was in most of the day for tests i dont know what to do next.

  16. Alec on Wed, 14th Oct 2009 6:36 am 

    Well, My dog has been diagnosed as having the early stages of Cushings and has been given vetoryl 60mg once a day. Is there anything else i should do regarding diet? and will his muscle wastage stop and rebuild itself?.

  17. Kevlyn on Sat, 17th Oct 2009 1:48 am 

    My large 86 lb, 14 year old mixed breed Airedale, was diagnosed with PANNUS. Where the immune system attacks the cornea part of the eye, I thought it was cataracts. He has been eating holistic dog food for over 8 years. He’s had 6 benign tumors removed in 2004. He is a sensitive nature. He has plenty of room to run. He walks daily as we live in the country. Vet wanted him on steroids, but liver enzymes were elevated. so the steroid is limited to eye drops which seem to help & somewhat suppress the immune response. I am taking for his health & from what I’ve researched, he needs a balance of brown rice, low protein, & green beans, broccoli. the green beans are preferred. I’m considering digestive enzymes for him. It’s the same with vets as with doctors, drugs & vaccines instead of a holistic approach. I found an herbal liver support which contains Mil Thistle, & product is ensured for efficiency. I hope this helps, I will find out at next blood work. He’s in good shape, building his hind quarters up by keeping him moving & he certainly deserves a good long life. The vets need to learn nutrition instead of putting a band aid on it with chemical drugs that are toxid to the liver to begin with. I’m sure it was the vaccines, or the heart worm pills doing it. One vet in his lifetime warned of these heart worm pills toxicity on the liver if given year around, which I don’t do. Next season, I will be using an organic parasite remedy instead of the chemicals they push that contain ingredients like sodium lauryl sulfate, (engine degreaser)in their so called arthritis meds. How dare they promote these deadly chemicals that damage the liver, & other organs under the guise of “wellness”!

  18. Tania Triantafyllou on Sun, 18th Oct 2009 1:21 am 

    My shih tzu, 5 years old is in very bad condition. We noticed that his abdomen was very bloated and took to the vet. Blood tests were done and shows that he has liver disease. He is taking meds, but he still the same. He hasn’t been eating for a week already – he is in a low protein died, UD. I would like to know if i can make some homemade food for him that would replace the one he is supposed to eat. Thanks, Tania

  19. Tania Triantafyllou on Sun, 18th Oct 2009 1:24 am 

    His diagnosis with Portosytemic Shunt.

  20. Joyce Sutay on Tue, 10th Nov 2009 5:10 pm 

    My 14-yr old schnauzer has survived pancreatitis at the age of 8 and the doggie equivalent of vertigo about three months ago. After noticing an enlarged stomach, lethargy,and not eating, I took her in to the vet. Testing showed dehydration and liver enzymes off the chart (unmeasurable – that’s how high they were!)…Ultrasound was normal for pancreas…Liver abnormal. After several days of bowel problems with meds to stop it, she seems to be better…enzymes have dropped about 1/4th … eating again….watching closely. Vet said two scenarios…either IS improving or liver not functioning at all. ???? I guess time will tell.

  21. Zorro's mom1 on Fri, 8th Jan 2010 7:16 am 

    I don’t know if anyone will respond to this post… but here we go…

    My little man had a seizure about 4 days ago. I have seen dogs have seizures before and my dog Zorro had a bad one, HORRIBLE shaking with wide eyes somewhat rolling around, with a blueish-gray tounge, and lasted for about 3-4 min. He started gagging towards the end and then finally puked and the seizure was thankfully over. He is not even 2 years old (but will be in a month) and only 15 pounds!!! I never thought that this could happen to my “little man,” but it did and I do not know what to do. He went to the vet several hours later and I had them take a blood test. The test results came in the next day with the results that his liver enzymes were highly elevated. The vet continued to tell me that this was highly unusual and his liver issues have nothing to do with his random seizure… she is dumbfounded and is not quite sure why his liver is in the condition that it is.

    I have done a decent amount of research online and I decided to add a little milk thistle to his diet (in hopes that it will improve his liver funtion) but I feel as though he might be a canidate for liver disease…?

    I wish I could afford to send him to any vet and get as many tests done as possible, but quite honestly I really cannot… I am trying to research everything myself to try to find out what is going on so I can afford the most important treatments for him.

    IF ANYONE HAS ANY IDEAS, THEORIES, ETC… please please let me know… any little bit will help

    thanks again,
    Deanne and “little man”

  22. Debbie and Tucker on Sun, 17th Jan 2010 7:16 am 

    Tucker has always eaten Science Diet food and has been fairly healthy…he does have PRA which is hereditary where he has gone blind. He started vomiting so I took him to his vet and found out he was dehydrated and have high liver count. He’s been there over night two times and the vet has put him on Science Diet LD and Denosyl and another chewable tablet. He eats it fine and has gotten better. The problem i am having is when I take him outside…he finds anything he can to eat. Is he not getting enough to fill his belly from eating this food?

  23. al rossetti on Fri, 19th Mar 2010 4:12 pm 

    our choc lab BOSCO 9yrs old had high liver blood count in dec.2009 was put on dynasol med for a month he got better a week after his vet visit march 18th 2010 he went down hill again i made an appt for him to see vet next day that night we rushed him to the emergancy vet hosp half hr. away when i checked on him at night about 3;00 he was seziuring so off we went to hosp they sedated him the seizers stopped but they said when he waked up if he is still in siezire that its not good well he started to siezure it was not good we oppted to have him put down BOSCO was a big kid (PUPPY ACTING) all his life we took his ashes home to bury them where he liked to lay outside his buddy CINDER is looking all over for him and mopeing aroung like us

  24. ilse poyato on Tue, 13th Apr 2010 7:24 pm 

    i really need help my dog is on a real bad condition with a lots of side effects from vetoryl i need to know if is any medication out there they can help to get out this please any one feell free to call me at 702-480-9494 that is my cell i really need help she is been on the hospital for two days any good doctor out there on any state who can help me please please call me i will fly out there , thanks

  25. Kylie Batt on Tue, 20th Apr 2010 3:43 pm 

    ?? ????? ?????? ?? ?? ?????. ? ??????. ??????? ???????. ?????? ??? ? PM, ??????????….

    ????? ?????? A year ago at Jake’s annual checkup a senior panel was done and his Alk Phos level was elevated at 360…..

  26. sebreana on Wed, 12th May 2010 12:27 am 

    can anyone tell me how to help my dog he has low liver enzymes i think, his bile acid is low i know.. hes had the problem before but now i realy dont have the money to take him in. he wont drink water or eat, hes bwwn haveing little sizerise for 2 days now. hes very tired but when i let him out side he seams fine. i finally got some yougert & popcicles down him last night but nothing else please help 360-306-1030

  27. l. Faye Saville on Thu, 20th May 2010 9:43 pm 

    My Dachshund(9 yrs. old) had blood work done. Came back with high enzyme level.She is going on meds tomarrow.And a special diet.She loves to eat.She was a sick puppy for two days.First time Molly has been ill and did not eat for two days.This is all new to me,glad to have this website.

  28. Pam on Thu, 27th May 2010 11:24 am 

    I am glad to have found this site. My english pointer/beagle mix is 13 years old and has been in the hospital since Monday. She has been diagnosed with liver disease. When the vet ran the blood work on Monday her ALT was 1500. He started her on an antibiotic IV and did an ultrasound and needle biopsy. No cancer or tumors found, but her kidney was enlarged. He ran bloodwork after 48 hours and her ALT went up to 2900! The antibiotic therapy wasn’t working. He sent her ultrasound results to a specialist and we’re waiting to hear back. Here’s my question: at her age is it worth it to have a surgical biopsy and send her to a specialist? I’m just worried that it won’t fix her and just end up costing a fortune. She’s been a wonderful member of our family. Any information would be appreciated.


  29. Doris on Tue, 8th Jun 2010 10:48 pm 

    I have a 9 year old pit bull, she walks around in the house in a circle ,following the same path. Like she is dioreinted. She has walked in to things, and has also has some sort of parlizies. Sometimes on her left side her feet turn under and she walks on her knuckles, back legs give out at times.Looks as though she doesn’t feel well.Ran several tests, shows high levels with her liver one is over 3000, the other over 2000.Had xrays done shows no signs of tumors or masses . Liver is enlarged. They put her on Zentonil 400 mg also she had been put on steriods and antiabotics (ear infection)She drinks alot eats,and just walks/paces and then lies down and shakes.She has been the best dog ever, I do not want her to suffer, but vet feels as though she has a chance. Like I said she is the loving dog, and I feel so sad for her,she seems somewhat better when I am home for awhile, she at least is trying,can someone, let me know if they have had a similar problem and what they did. Thanks Doris

  30. Webmaster on Thu, 10th Jun 2010 11:35 am 

    Please e-mail me your contacts. I have a question webmaster@spottovo.ru” rel=”nofollow”>……

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  31. Katie on Tue, 22nd Jun 2010 2:09 pm 

    360 sounds like a very high liver ezyme count. Normal is 120. My dog was just tested at 145 and I am working to getting it lowered. How is Jake doing now?

  32. Roger on Thu, 28th Oct 2010 11:06 pm 

    Just returned from the vet with my 11 year old Bichon. Her liver count was 2000. He said it was probably liver disease, liver cancer, etc. Gave her about 2 years to live. He also has her on
    Denosyl 225mg per day.

    Your thoughts???

  33. Patty Van Allen on Fri, 26th Nov 2010 11:36 pm 

    Our ‘Regal” (rat terrier/beagle), “Honey” got very sick/lethargic a couple weeks ago. Thought she was about to die.
    Asymptomatic for anything liver related, but has off the chart-unmeasurable liver enzymes. Had lots of bacteria in her stool, high white count & a little low red blood count.
    Course of antibiotics got her feeling fine in a day. Giving her SAM-e daily as well.
    History-chen profile showed high liver enzymes about 3 years ago, also asymptomatic. Gave her omega-3 fatty acids then for about a year but didn’t repeat the blood work since she had no symptoms.
    X-ray & exam was normal!
    We go back next week but I’m thinking the enzymes will still be up. We’re worried about our little girl! Thinking she may have damaged her liver when she was a stray b/4 we got her…?

  34. Lisa on Sun, 28th Nov 2010 6:54 pm 

    Hello Patty,

    Thank you for your email. I am sorry that you are having to go through this situation. I know from personal experience how terrible it can be.

    I think you are on the right track with the antibiotics (some dogs remain on those for life) and the supplements.

    I would encourage you to ask your veterinarian about a few other medications and supplements as well that are liver-specific:

    Lactulose – Lactulose works in the large intestine to minimize the production of ammonia by bacteria. It does this by changing the pH and converting ammonia to a form that is not readily absorbed into the bloodstream. It also stimulates normal colon bacteria to absorb ammonia, which is then passed in the feces. Finally, it stimulates the intestines so that ammonia passes through faster, which means there is less time for absorption.

    Corticosteroids – Cortisone is used if there is evidence that the immune system is implicated as a cause
    of the liver problem.

    Ursodiol – This drug replaces toxic bile acids with a type of bile that is less toxic

    Certain homeopathic remedies can also be very helpful when treating canine liver disease. Natural herbs and substances such as burdock and greater celandine have properties that assist with the purification of blood, the stimulation of digestive enzymes, and the protection of the liver from toxic substances. Also, some such substances have anti-inflammatory and antibacterial properties.
    Milk thistle is another natural ingredient that is known to be very effective in cases of canine liver disease. This natural substance acts as an antioxidant like vitamin E, stimulates production of new liver
    cells, and helps to prevent certain toxins from attaching to the liver.


    I would also recommend making some dietary changes as well to help her liver function more effectively. Dogs with liver disease need to be fed smaller amounts of food more frequently (4-5 small meals per day if your schedule allows). There are certain types of protein that are easier for the liver to break down as well so it doesn’t cause as much trauma internally. Here are some links from our website on liver-friendly diets:





    There are many reasons why there may be high liver enzymes. Anything from medications to genetic predisposition to trauma or bacteria can cause liver enzymes to be ‘off’. It is important to try to get as firm of a diagnosis as possible in order to design a treatment plan. Often times diet and supplements and medications are necessary regardless of the diagnosis so those are good places to start. Here is a little bit more information on the specific liver enzymes:

    Important Liver Enzymes
    Traditionally the medical practitioner has measured the relative concentration of several enzymes which may indicate alterations in liver health. The following enzymes typically change values in the face of liver failure

    Alanine Aminotransferase: ALT – Liver specific. Cell damage will cause elevations of ALT due to leakage. The elevation of the enzyme correlates with the number of cells damaged. Falling levels of ALT may indicate recovery or may indicate a failing number of functional liver cells. Rapid increases in ALT may indicate an acute process, while slow increases may indicate bile duct obstruction.
    Normal Test Range: 10-100 U/L*
    Aspartate Aminotransferase: AST – an enzyme seen in the liver, heart, kidney, skeletal muscle and brain. The half life of the AST in the blood stream is much shorter than that of ALT, therefore the values of AST tend to drop more rapidly once liver function is resumed. AST elevations and ALT elevations should parallel each other in liver disease
    Normal Test Range: 5-55 U/L*
    Alkaline Phosphatase: ALKP/ALP – This enzyme is present in many tissues, therefore it not very specific in liver disease, but it appears very early in the progress of liver disease, therefore it is considered quite sensitive. ALP tends to be slightly more specific in the cat, but not quite as sensitive. A similar enzyme or isoenzyme is secreted as a result of high levels of cortisone, therefore an effort must be made to separate Cortisole induced ALP or CALP and normal ALP. Liver ALP is released from the liver when many anticonvulsant drugs are administered to the dog. This must be taken into account when evaluating ALP levels. ALP levels typically are greatly elevated in the young, growing animal and therefore a veterinarian should not mistake any elevations as disease in a young animal.
    Normal Test Range: 23-212 U/L*

    Also, have you had a bile acid test done? That is usually the next step after enzymes are found to be high. It is a simple blood test and is non-invasive and VERY sensitive to test the functioning of the liver. This will determine if the liver is indeed damaged or if something else more superficial is causing the high enzymes:

    Bile Acids
    These series of organic acids circulate almost entirely in the localized blood flow between the intestines
    and the liver (a.k.a. the Portal system). The flow is typically from the liver, into the bile duct system, then excretion into the intestines to aid digestion after a meal, to be re- absorbed into the portal system and recycled by the liver. Very little of the bile acids escape from the portal circulation system into the rest of the body. Leakage is considered abnormal and is a sure sign of a liver abnormality. This is one of the most sensitive tests available to diagnose liver disease. While the liver does actually manufacture this product, it has tremendous reserve capacity and can easily meet the bodies demand for bile acids despite severe disease. As a result of this reserve, the bile acid levels do not typically drop due to liver disease.
    Normal Test Range: Pre = Less than 7.0 umol/L, Post = Less than 15.0umol/L*

    I would also recommend joining a couple different online groups that I am familiar with that were created specifically for owners of dogs with liver disease. The people on these groups are VERY helpful and often times have more direct experience treating dogs with liver disease than a traditional vet. They are knowledgeable and happy to share their information with anyone who asks. The links for those are:



    I hope some of this information is useful to you and that you can get some answers and help treat your pup and make her healthy again. I will be keeping you in my thoughts – please keep me updated as to what you find out!

  35. Patty Van Allen on Thu, 9th Dec 2010 11:46 pm 

    I SO appreciate your thoughts & valuable info, Lisa, I know you are aware of the fear when a beloved pet is ill.
    We had a really good report from the vet when “Honey” went for her re-check. Enzymes went from unmeasurable to ALT-188 (still way hi but so much better) ALKP-201 GGT-30.
    We’re giving her SAM-e and when finished will give milk thistle. Also doing some of the ‘liver diets’.
    I feel so bad for those who have posted about losing their furry kids. We all go thru this but it never gets easier.
    You are a jewel for statring this website.

  36. Colette on Wed, 16th Feb 2011 9:02 am 

    I agree with Richard. At some point, if the dog is not eating, going downhill, and suffering, the decision must be made for humane euthanasia rather than letting the dog die a painful death. A dog that gets more and more run down, is nauseated, can’t eat, is a dog that dies in pain. Too often, I think we hold on for our own needs, not the needs of the dog. It is disturbing that not enough vets help make that difficult but necessary decision. Giong on with endless tests doesn’t take the pain away. It is also inportant that sick dogs be on pain medication in appropriately high doses. A dog in pain means added stress that detracts from getting better. But if there is no hope, if a dog does not eat and time passes and the dog is clearly going downhill and no one has an answer or a fix, please don’t let the dog die in pain. Herbal or natural remedies don’t cure pain. Providing a painless end is one of the most important things we can do for our dogs qwhen the time comes, instead of waiting too long while the suffering continues.

  37. Colette on Wed, 16th Feb 2011 9:25 am 

    One possibility for liver disease may be environmental exposure.

    For example, when we take our dogs for a walk, they walk down the street where cars were parked or driven and have leaked oil, gas, antifreeze, which is either ingested through paw licking or through the skin.

    Also I see people have these lawn service companies (or do it themselves) dumping chemicals all over lawns and gardens, then allowing their dogs to romp on these poisons. (Or their lawns are poisoned thanks to the neighbor’s treatments) The lawn chemical companies always deny there is a problem. But it is common sense that these chemicals are toxins.

    Even if we choose not to use these chemicals, fertilizers, and herbicides, when we walk our dogs, they may walk right through grass or gardens treated with these poisons, or on a sidewalk or street that has a residue thanks to run off.

    Environmental poisons are so prevalent in our society. Add in bug spray treatments, having a pest control company spray your house or garden or using rodent poisons, drift from farm spraying, a neighbor having trees sprayed. Even if we choose not to use them, our neighbors’ and local businesses’ use of toxins can affect our property and the parks and sidewalks.

    Someone I know came to spray her house for ants. The guy had rodenticide from another job in his work bag, and the dogs found it. Emergency treatment saved them because she happened to catch them, but who knows what long term damage has been done.

    A dog can swallow poisons like this in the blink of an eye, for example when visiting or romping off leash, and no one knows it happened.

    There are so many alternatives to some of these chemicals (such as organic safe lawn fertilizers or sealing up food sources and entry ways instead of poisons for rodents, etc)

    But so many are out of our control, such as car toxins.

  38. Sue Harris on Fri, 22nd Apr 2011 10:34 pm 

    My 9 year old shih-tzu had her regular check up with blood work. Her reading on her liver was 300 but everything else was normal. She has always been a healthy dog and is not showing any symptoms of illness, Our vet put her on Marin 1/2 tab per day and he also put her on Clavamox twice a day. She has an appointment in three weeks to recheck the blood/liver. My question is would it hurt to put her on Sam-E and Liver a natural glandular supplement along with the two things she is on through her vet? She is on a raw diet through Nature’s Variety which she eats the canned and the dry food. The vet also added if the reading isn’t any better, that he could get a sonagram on the liver. Just would like some feed back from you all, it seems like you all know alot about this particular subject. Thank you ahead of time. Sue Harris

  39. Jaime on Mon, 2nd May 2011 5:26 am 

    I just found out my 4 year old Cavalier has liver problems. Xray shows she has a small liver. her ALT levels are hi and im taking her tomorrow for ultrasound and/or biopsy. The dr gave me that Sam-e stuff but for some reason i cant get my dog to swallow the pill. the instructions say to feed on an empty stomach…when i finally did get her to swallow one of the pills she threw it up…this is so upsetting to me and shes now starting to turn yellow. im so scared for her. i dont want to lose my best friend!

  40. Cookie on Sat, 21st May 2011 3:01 pm 

    I really appreciate all the information listed him from everyone. Especially Lisa at the bottom. My Cookie has had high liver enzyme levels for the last 5 years and they have gotten higher in the last year. Ultra sound was done and no tumors found. I am going to have further tests done for she is bloated and my vet said it is not related but I have read here several owners saying it was. Thank you all again.

  41. Patty Van Allen on Sun, 22nd May 2011 10:13 pm 

    Just wanted to give some encoragement to others, our “Honey” I wrote about in Dec/10 has made a remarkable recovery.
    We started her on milk thisle after about 6 wks of SAM-e. Also cooked her meals-the recipes are great.
    She had her annual app’t last month and not only are the enzyme levels down, they’re less than 10!!
    Perhaps we cought it in time, maybe its a ‘good’ kind of liver disease to have, or maybe prayers helped. We are eternally grrateful at any rate, and credit this website for most of the success.


  42. Jill Boyce on Mon, 23rd May 2011 3:55 pm 

    My dog Jess is my baby. She is 11 years old and last week I had to take her to the vet as she was in season and sometimes the blood was clots instead of her normal spotting. They thought she had an infection in the uterus as she hadnt been spade. They told me to take her back the following day and booked her in for the proceedure. My phone went 2hours after to say they had taken blood tests before the op and her liver enzyme levels where elevated. They did a scan and nothing showed up but did say there could be a small tumor in the liver. They gave me some anitbiotics, prednisolone and tab to help with the digestion. I have to take her back this wed and i am dredding it. She is my baby and friend and I talk to her all the time. I have started her on milk thistle and burdock root. This was devastating news as she is eating and drinking and seems her notmal self. She is panting but thats all. I pray each night that she will not die yet. I love her so much

  43. Jodee weaver on Tue, 24th May 2011 10:34 pm 

    Hi all,
    My 10 year old Scottish terrier has an Alk Phos of 9,330!!! Not sure what direction to take.

  44. sharon brown on Wed, 25th May 2011 2:59 pm 

    Hi, I have a 9 year old yellow lab that has grand mal seizures. He has had them for 6 years. Has been on Pheno barb and his liver enzymes are high. Recently we took him off pb because he started having Ataxia and weakness in hind legs and started him on Zonisamide. He has quit eating except for some chicken. What can I feed him?

  45. Sandy on Thu, 26th May 2011 12:15 am 

    I also want to give some positive remarks and encourage you to see a good vet, as soon as possible. My 14 year old terrier was getting a bit lethargic but I put it off to age. Then she was limping a bit and the local vet found a sore in her foot and put her on some powder to improve it, which it did a bit. But she continued to get more quiet, picky eater. Finally I found her one morning last November, shivering, which my dogs never do unless they are in pain. I rushed her to a specialist, an internist, nearby that I have used before and are VERY good, for tests and an xray. Suggested the liver was abnormal. Very high liver enzymes. So we did a biopsy. It is not that intrusive, as they use a mild sedative and they can reverse it quickly. The results of the biopsy were bad. She had a liver like swiss cheese, very toxic liver. Hepato cutaneous syndrome. I actually was relieved because I had lost two dogs to liver cancer recently and was afraid it might be in the line. But still a serious disease, perhaps caused by something toxic she got in the environment? By now her feet were so sore she would not walk on them, all four involved with rough scaly sores. And some scabbing around her eyes. Specialist recommended IV of Amino Acids flushing the liver. The liver is fortunately one organ that can heal itself if not too far gone. So Katie spent a day at the vet on IVs. It made her nauseous so we had to give her reglan and an appetite stimulant, mirtazapine? (actually an antidepressant that seems to stimulate appetite in dogs)…so she would eat. I made all kinds of things to entice her, and had to vary them, but she did eat. Two weeks later she had another day on the IVs. Each time she came home exhausted and very tired, but I kept at it and it only took two treatements in her case. I also consulted a homeopathic vet who prescribed two very good supplements from Standard Process Products, Hepatrophin and Super EFF. I was told adding egg would add amino acids as well, but she would not eat them. I took her off the silamarin as the holistic vet felt it was of minimum help. Finally, after noticing a lot of water consumption and urination the vet put her on baytril for a week or so. That was the final push and she started to get well quickly. Her enzymes are still somewhat elevated, and she does now have very mild diabetes but a small shot of insulin 2x daily is a small price to pay for keeping my girl around for a while. She doesn’t even notice them. Her feet are totally healed and she got a great checkup yesterday at the vet. Her energy is back and she is eating well (tho still picky)…so miracles do happen. Your dog can recover with the right treatments. If you would like a referral to my holistic vet, Dr. Chalmers in Santa Rosa,CA let me know. I think she is great, affordable and she treats by phone. And VMS in the Bay Area is in my opinion, the best veterinary practice I’ve ever used. They have treated many of my older dogs and I have nothing but admiration for them. Katie is nearing 15 now, and I know I will eventually lose her, but not today. Not tomorrow. We have a bit more time together. Keep the faith and explore options. Dogs can recover.

  46. Sandy on Thu, 26th May 2011 12:25 am 

    One other suggestion for those of you trying to get your dogs to take pills like denamarin. It is a very large pill. There are smaller doses available that can be given as two pills. And a wonderful product, pill pockets, can hide the pill in a tasty ball so that they don’t even see it and swallow it whole. I also use cheese and raw hamburger. Just a suggestion.

  47. Samantha on Fri, 3rd Jun 2011 1:22 am 

    I’ve only had my mini schnauzer for 2 months. Day three when i got him, took him for vaccinations and he got realy sick. Same thing happened on second set of vaccinations. I thought attributed all this to adverse reaction to vaccinations.A few days ago, he had no appetite, no energy, and ended up having a seizure. During this time, we had him on the same diet the breeder had the puppy on, which was puppy chow. Long story short, we took him to the vet and had tests ran. Liver enzymes were extremely elevated and vet says it will be a huge financial investment if we keep him. My question is, is there something we can do to treat liver damage, put some weight on him, and prolong his life without him suffering? We love the little guy and don’t want him to suffer, but scared he may have another episode that may be his last. Please help.

  48. Mike on Mon, 20th Jun 2011 6:31 pm 

    I have a 3 yr old dog and switched his food to Orijen few months back. He went in for his yearly blood panel and his liver enzymes were very high. After a $350 ultrasound and more blood tests, we decided to change his food. 1 month later all levels normal. Be wary on vets who just want to test. There is endless amount of money to be made.

  49. Mandy Barre on Sat, 2nd Jul 2011 8:08 pm 

    My lab has had highly elevated alk phos for 14 months. We found it during a routine pre-surgery check. She was put on Denosyl and retested in a few weeks. Same result- alk phos off the charts. She is clinically fine, running playing jumping and is 11 1/2 years old now even after this diagnosis! Still eating and weight is the same for the last 2 years. I just had her retested and it’s still over 2000. I switched her to (Source Naturals) SamE 12 months ago instead of the Denosyl due to price, twice a day on an empty stomach. This is the same or similar to Denosyl and she gets 400 MG per dose-(you could do smaller- I’m experimenting with 200 in am and 400 in pm.) I give her the SamE with a small treat as I think it’s upsetting to her stomach by itself. It’s important to get SamE that is in foil packets. Any comments on this?

  50. Jane and Gus on Sun, 7th Aug 2011 1:12 pm 

    We have a 10y.o. female, black lab – Xena – with elevated liver enzymes (1800). She’s been on Denamarin (started out on Marin) for the last couple of years and has her blood tested every couple of months. She eats Natural Choice dry food. At every lab test her enzyme levels just keep going up. She has aggression issues, so the vet prescribed Prozac, which she’s been on for the last 4 years. Btw, her enzyme levels have always been elevated, even before she started Prozac. Originally the vet thought she might have Cushings – excessive thirst, lethargy, etc. – negative. Her bloodwork in June came back with levels at 600, the most recent 1800. How can that be – numbers tripled in two months??We haven’t changed/added anything. It’s frustrating. The vet has this “wait and see” attitude. I don’t want to wait for Xena to get so sick, that by the time the vet decides to do a sono/x-ray, whatever, it’s too late to do anything. I’ve been feeling that the vet is just dragging out this process, when she should be looking for solutions. I’m really worried. Xena hasn’t been looking good at ALL lately. She’s been very sensitive about touching her torso area – which looks enlarged, for sure. She’s still eating fine, but she’s a Lab. The day she stops eating will be the end. I just don’t want her to be in pain. Any guidance, suggestions – they would be GREATLY appreciated. Thank you!

  51. Sarah Thompson on Fri, 9th Sep 2011 2:01 am 

    Just need some answers like so many of you…
    I have a 5 yr. old Schnauzer who started having seizures 2 yrs ago. Started have bloodwork done and recently found her Alk. Phos was up to 900′s. We’ve done so many tests and are about to do a bile acids test. I don’t know when I should stop the testing and let her live. She seems happy and healthy to the appearance. Anyone else have a similar situation?

  52. Lisa on Sat, 10th Sep 2011 9:52 pm 

    My 9 year old corgi mix was on a high dose of pred for allergies. Just after stopping the meds he became excessively bloated. The vet ran blood tests & did an ultrasound. Nothing wrong inside. Blood work only indicates slightly higher liver enzymes. He is so bloated he can barley walk. I am feeding him chicken & rice & taking him to the bathroom to pee. No poop yet :.( Vet is stumped. He is alert but sometimes tired. DOES ANYONE HAVE ANY IDEAS TO REDUCE THE BLOATING? I am in tears & desperate. Thank you.

  53. Lisa on Sat, 10th Sep 2011 10:57 pm 

    I am sorry to hear that you are going through this, I know how horrible it can be.

    There are so many variations in diagnosis and treatment as well as length of life after a diagnosis.

    What I would like to do is refer you to an online group that is very experienced with this type of issue. This group is specifically for owners of dogs with liver disease and many of the members have owned and cared for multiple dogs at different stages of the disease. I know that there are members of the group that share your diagnosis and I feel they would be most helpful in giving you some good information. There are even a few amazing stories about dogs with terrible ‘final’ diagnoses that have gone on to live longer, healthier lives with a good quality of life. I would encourage you to join this group, give your information and ask the members your question(s).

    They often ask detailed questions about liver values, tests, etc so be sure to have that information handy and they can give you some suggestions and their experiences as well. From the time I have been involved with this group, I have seen how caring and helpful they can be and most people are able to glean some very useful information and support while participating in their discussions.

    Here is the link:


    The treatment for most liver disease issues, other than copper storage disease (rare) and cancer is pretty much the same – supplementation and prescription meds, as well as dietary changes. Sometimes these things alone can reduce the effects on the liver and bring the liver enzymes down.

    Sam-e is a fairly common recommendation, along with milk thistle. These are fairly inexpensive supplements that can be purchased at many health food stores as well as places like Wal-mart, Costco and Target stores. These supplements help to detoxify the liver and aid in regeneration. Here are some recommendations on dosage:


    I would recommend that you put your pup on a ‘liver-friendly’ diet of some sort. Liver dogs need to eat more frequently in smaller amounts than normal dogs and they need certain, more-digestible, forms of protein. Here are some suggestions from our website:





    There are also some prescription liver diets available from your vet from Royal Canin and Hills.

    This disease varies greatly from pet to pet and there isn’t a definite timeline for survival or even for showing symptoms. Some dogs that I have known with DIRE #s and symptoms have outlived dogs with lower numbers and less symptoms, there is just no rhyme or reason sometimes.

    You must be your dog’s health advocate as many vets do not know that much about canine liver disease. Do not be afraid to ask questions, make suggestions and even demand tests and medications if you feel you are not getting the results you deserve.

    I hope that you can get some comfort and answers with this information. I will keep you and your family and your pup in my thoughts.

  54. kim simons on Tue, 13th Sep 2011 12:49 am 

    Call Wilma Jean Dodds with hemopet in California she is the reason my dog lived to be 18 with severe liver disease since she was 6 yrs old

  55. Jenny on Thu, 17th Nov 2011 2:48 am 

    I so wish I had found your website a couple of months ago! I just said good bye to a beloved, family member, Spanky. She was found at a Petsmart adoption at 7 and was 14 when she passed. Having her go to sleep in my arms was sad beyond belief. Had I known about this site, I would have asked my vet more questions earlier in the year, and done more sooner, other than liver pills that really only seemed to make her sicker. She stopped drinking water, would only eat baby food from our finger, and just became confused and scared. Her little spirit has left a hole so much larger than her 12 pds. If I can ever bring myself to get another friend, I’ll take it upon myself to learn more sooner.

  56. Melissa Hiatt on Thu, 5th Jan 2012 4:10 pm 

    I to am having problems and not sure what to look for as far as know if my dog is getting better or not. I have a bull mastiff/pitbull mix he is 9 1/2 years old and he almost died of a prancreatic attack when he was 3 and I have been worried every time he coughs or throws up, he also has food allergies and rheumatoid arthritis he was taking pain meds for the arthritis but it caused him liver damage so I stopped and now he gets laser therepy and works wonders so one less thing to worry about. He had what I thought was another attack during new years weekend and I got him into the vets as soon as I could and they did a full blood panal and found his pancreas was fine but he has a chronic liver infection his ALT was 280. Does anyone what what signs to look for to see if he is getting better?

  57. Julie on Sun, 29th Jan 2012 1:25 pm 

    Need help. We got a wonderful 3 year old red Australian Cattle Dog, Wally, from the humane society. Wonderful, except he drinks excessive water and excessive urination. We limited his water to 8 oz in the am and pm, but he still needs to go out about every hour. He also dribbles in the house at times. We took him to the vet and found he has liver enzymes of about 800 and his urine was like water (clear and low s.g.). Took him back a couple of weeks later and his urine was normal, so this is not diabetes insipidus. I have him on denosyl 225mg and may get his liver enzymes tested again…but he is the picture of health otherwise. What to do? The frequent urination is driving us crazy! Can you help?

  58. Jill on Thu, 11th Oct 2012 10:00 pm 

    My 13 year old jack russell had elevated alkphos(1650) and Alt (330). Had surgery for a mass on his liver but they had to leave it in, it was non cancerous, as were some nodules that they biopsied. He did come out with a case of pancreatitis, and now it has been 3 months on a low fat diet and the liver enzyme numbers are slowly coming down.

  59. gidget nelsen on Thu, 28th Feb 2013 7:55 am 

    looking for sam-e 90mg for 10 lb dog and i need it in liquid or crushabletablet

  60. cherie from nc on Fri, 31st May 2013 5:14 am 

    I have an aussie collie mix and she has been so sick. Can’t keep water down but wants to eat. We went to the vet today and her liver test came back 13,000. Is that even possible. Should she be dead? The vet gave us fructose: in a syringe to give her plus nausea meds. She is on tramadol for hip pain and steroids. She is 13 and the only dog i have ever owned. I have changed her diet and monitor her water because she is really thirsty but throws it up after drinking. I would love some suggestions. She breathes hard and only wants to go out to use the bathroom then right back in. I thought i would get some sam-e and milk thistle and try it. Not sure what to do. Need help.

  61. Gail on Mon, 10th Feb 2014 1:00 am 

    My bichone just started dribbling urine after he releases his normal flo he also had a little blood one time they were also little drops he’s eating well and active he is constantly getting checked I give him hard food and little ceases mixed he has a healthy appetite I’m a nervous wreck I’m afraid to bring him in again he was there just a few weeks ago they gave me meds for him should I wait to see if he improves
    P.s. he has inflamed gums what do I do he won’t let me near his mouth he clamps his jaws

  62. Jane on Mon, 24th Feb 2014 10:32 pm 

    My border collie was vomiting and not eating a couple of weeks ago, so took him in to the vets – they said his ALT values were about 2,000. They kept him for three days and gave him iv’s, then let me bring him home since he wouldn’t take his meds (Denamarin) for them. Now it is a couple of weeks later, he seems to be feeling much better – eating, drinking, asking for treats. I took him in for tests – ad they said his ALT was still about 2,000 although he is doing better clinically? I don’t get it….have to take in back in another two weeks for recheck. Can anyone shed some light on what may be going on?

  63. michelle on Thu, 27th Mar 2014 2:25 am 


  64. gerie owens on Tue, 5th Aug 2014 11:46 pm 

    i have a 14 yr old jack russell named Commander Dax who’s alkp is raising.. now at 452.. vet did ultrasound and has tumors or abnormal liver… she did say i can take him to a specialist for biopcy to see if benine or cancerous but don’t see the point in putting a 14 yr old dog through that… he has been anemic for last 3-4 yrs.. on pet tinic.. his symptoms are, letharic, swelling/bloated look (vet said it’s the area where liver is so makes him looks bloated).. vomiting/upset stomach, i’m giving him pepsid twice daily and have cerinia on hand for when it gets bad.. diarrhea, which comes and goes.. on flagyl when he gets it and denamerin for his liver.. won’t eat his own food anymore, will on occation eat low residue iams, which i feed my cocker. vet told me i’d have about a month with him, then i’d probably have to put him down.. it’s been a month, took him back in today and alkp is up from last visit, but that’s the only liver value going up… besides his anemia values blood work looks good.. just can’t eat without getting upset stomach and diarrhea… just for my piece of mind.. does anyone have any idea how long i would have him around for.? vet did tell me that when he stops eating, that would be when i have to bring him in to euth.. so far i can intice him to eat something…last few days has been rice and baby food 3 times a day.. sometimes i can add dog food (the iams) sometimes can food (that’s how i hide his meds) thanks

  65. Julie Ralston on Wed, 20th Aug 2014 9:08 pm 

    Okay….I have a 9-year-old Australian Cattle Dog. She has been diagnosed with chronic active hepatitis and cirrosis. She as had many many tests: biopsy, ultrasound, bloodwork. Everything has been SUPER elevated. To maintain her life, it will require monthly blood work ($200), a specialized diet ($40/12 cans), and three medicines, one of which is prednisone which makes her thirsty, hungry, and makes her urinate a lot. Per the vet, looking at her numbers from the battery of tests she has undergone ($9K), they say that her numbers are NOT good, but that she looks great. While another dog may be “dead,” she seems okay….as long as she is on all these meds. I took her off the prednisone, and within a couple of days, she was vomiting and very sick. SO…. her health is horrible, yet she seems happy. Do I wait until she is in pain and feels horrible? Do I wait for a panicked horrible situation where I have to rush her in and she is not stabilized, or do I do it now? After four months, her numbers are still very elevated. She is my BABY, but this disease is chronic. She has to see an internist because standard vets aren’t equipped to handle this. They don’t even seem to know the answers. I’m not sure what the monthly blood work is doing because nothing is going to cure it. I just don’t know what to do! :(

  66. Susan on Wed, 1st Oct 2014 9:23 am 

    I just lost my most beloved canine Ebony, best and truest friend, loyal companion, playmate and life partner for 14 years. I was feeling guilty about not having taken her to the vet sooner, but after reading of others’ experiences, I feel lucky that my dearest Ebony lived her life to the fullest, and played ball before collapsing and finding hard to stand. I had just come back from my daughter’s wedding interstate, and she could not stand up to say hello, but her face was full of enthusiasm to see me. When I couldn’t get her to stand, I called the emergency vet and took her their on Friday at about 11:00pm. The following day, she had not improved and they advised that she had pancreatitis and UTI and her fever had not gone done, despite IVD, antibiotics and painkillers too. I knew she probably would not last the night, but I was hopeful. (When she was 2 1/2 yrs she got seriously ill, vomitted bile, the vet predicted death, he could find nothing wrong when he cut her tummy open, so he just sewed it back up and continued with her antibiotics…but she never gave up, and two weeks later, though week and needing a special diet, she had fully recovered.) Even though I am grieving for her I still realise how lucky I was to have her for as long as I did. We said our goodbyes, it was so hard, but it made her happy …yes even near the end she still gave me that look of contentment…..then she closed her eyes. A couple of hours later I received that dreaded phohe call. I was in shock, but agreed to allow them to do an autopsy. They found that one of her kidneys had failed and was infected with multiple abcesses, and her pancreas was very swollen. Until reading this site, I was blaming myself for having not taken her to the vet for about 8 months, but knowing that it may not have made a significant difference, and even may have resulted in her being euthanised earlier in her life, I can now accept that my puppy is gone, and that I am not to blame for her death……but can be happy that she lived a life that was full of love affection plenty of play and loyalty from all who met her. She was my companian and her death has affected me more than I could ever have imagined, I can only say that the only thing that might be harder is to lose one of my children. Thank you Ebony for giving so freely of your heart, your loyalty and your devotion…..you were my life partner for the past 14 years and I am missing you so much already…In memorium

  67. Alexander on Mon, 6th Oct 2014 4:35 am 

    Hello. Today is my 13 year old half dachshund half shitzu’s, last night. He was a very healthy and energetic dog until monday of this week (today is Sunday). When we fed him monday, tuesday, and wednesday he got sick every time after we fed him. On Wednesday we tried to only feed him bland meat so it would be easy for him to digest but he still got sick. He became very lethargic and stopped barking. Primarily sleeping. He drank a lot more and his urine became an odd color. On thursday we took him to the vet and they took several tests and found out on Friday that his liver was no longer functioning. After going in for more tests and shots on saturday we left him there over night. Going there today we learned he hadn’t gotten any better and had indeed got worse. The undersides of his ears are yellow and his abdomen is swollen and red. We took him home for his last night. He has barely moved and we have to help him get up, move him, and lay down. It is heartbreaking to see him get like this so quickly. The vets say there is no way to figure out if it is just from old age or if someone poisoned him (since neighbors had recently complained of his barking to animal control).
    Please bring your dogs to the vet as soon as you have a sign that they are not healthy. You never know when it could be something as heart shattering as this. I grew up with him as my companion since I was 5 and it is devastating to have to let him go but there is no hope for him and he would only suffer if we let him. I love you clifford. And if anyone finds it okay to poison these innocent creatures than you are sick and deserve the worst.

  68. Andrea O. on Thu, 7th May 2015 3:38 am 

    I am so thankful to this website and everyone on it! My precious Yorkie, Emma Marie, just turned 5 years old (I was told she might not make it to her first birthday). Emma is having some health issues re: her liver and the vet put her on Clavamox and Flagyl. I’ve read posts that said other dogs were given it; however, when I googled it, I read that if your dog has liver disease don’t give Clavamox. It scares me to go ahead and give. Any advice greatly appreciated. Thanks to all.

  69. kevin on Sun, 17th May 2015 10:33 pm 

    I have a terrier mix he was diagnosed with Liver enzymes that were elevated and a lymph node that was inflammed. The vet says she has moderate liver disease. He is acting like he want to eat everything but when left down to him he doesnt eat. They done a scan on his liver and it looked pretty normal and they couldnt see any tumors. Sheis in great form but just acting like a picky eater but never was. He picks at pedigree but very little. He doesnt want chicken. He will eat brown bread loaf,ham,brocolli but i know these arent great.Any help would be appreciated! Thanks!

  70. Luis on Sun, 21st Jun 2015 12:47 am 

    Hi , my 12 yr. old pitbull had an elevated alkaline phosphatase and also elevated ALT about two months ago when my vet drew blood from him.

    He`s on 150 mg. sylimarin until the new blood test in two weeks time.

    He has had this issue in the past about 5 or six times.

    I feed him a home cooked meal , with all the supplements , designed by a veterinary nutritionist.

    I would not be so worried except that my other dog has also elevated levels of Alkaline Phos.

    My vet is not worried about this , he thinks that because of his age he will be having this elevated levels in the future.

    Does anyone know if this can be due to too many supplements ?

    It seems as if I`m feeding him too many beacause of the number of pills but the doses are really within the normal ranges.

    Thanks a lot

  71. Sammy on Tue, 16th Feb 2016 10:22 pm 

    My little Maltese was really sick because he stop eating. He was 11 yrs old. If I can think to what happen. Weeks ago he kept drinking water and peeing every few hrs. not normal. He did this through the night. I thought that he was old. Next few weeks, I gave him a Sprinkle cupcake made for dogs and it was very small 3 inch. The following morning he threw up and kept drinks drinking water and throw it up. He then ate less food each day ad his urine was darker yellow. The next day he didn’t eat at all and I took him to the Vet and he turn yellow. The Vet said he has diabetes and pancreatis. His liver enzymes were very high. He suggest to bring him to emergcy and have him get him to lower the high level of enzymes. He got help and we said goodbye for the over night ICU care. He look better with insulin and left him with good care. The next call from Vet said he might need surgery on his gallbladder. He went to see him and his eye look cloudy and his mouth was bleeding. He looked bad. We decided to put him to sleep to stop the pain. His condition did not look better and his enzymes went up higher. He was feed through a tube so we can’t even take him home. It was the hardest time in my life. I hated seeing my dog in pain and they say he had hepatitis too.

  72. william peets on Thu, 19th May 2016 7:43 pm 

    My little girl (10 yr old Shih tzu.) started sleeping all the time and didn’t want to eat drink. Went to Asher’s vet hospital and they did a blood panel and gave her IVs and pretty much said I should put her down, even wrote on my chart I would be back with in 8 hours to have them do it, as I said no she’s not in pain and were not ready to go. That was on may 5th and today Paisley and I just got back from playing at Shasta Dam, she still sleeps more than she used to but eats,drinks, poops and pees and sleeps with me and snores every night. I’ve been giving her 1/2 a tab of Denamarin 225mg every day. Must be working or helping, all I know is I love each and every day we get to be together. LOVE is a FOUR LEGGED WORD

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